Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling

傲慢与偏见

Evolution of the novel coronavirus from the ongoing Wuhan outbreak and modeling of its spike protein for risk of human transmission

傲慢与偏见

The occurrenceof concentrated pneumonia cases in Wuhan city, Hubei province of China wasfirst reported on December 30, 2019 by the Wuhan Municipal Health Commission (WHO, 2020). The pneumonia cases were found tobe linked to a large seafood and animal market in Wuhan, and measures forsanitation and disinfection were taken swiftly by the localgovernment agency. The Centers for Disease Control and Prevention (CDC) andChinese health authorities later determined and announced that a novelcoronavirus (CoV), denotedas Wuhan CoV, had caused the pneumonia outbreak in Wuhan city (CDC, 2020). Scientists from multiple groupshad obtained the virus samples from hospitalized patients (Normile, 2020). The isolated viruses were morphologicallyidentical when observed under electron microscopy.

武汉新型肺炎病例和海鲜生鲜市场有关联。

从住院病人体内获得病毒样本，电镜下观察形态一致，病原体确定为新型冠状病毒，命名为Wuhan CoV。

傲慢与偏见

2020.1.10 公布WH-Human_1基因组测序序列，其后陆续增加5例测序结果。

新型肺炎和2002年SARS存在一定的相似性，同样发生在冬天，有活体动物接触史，病原体同为新型冠状病毒。

截止至2020.1.15，有实验室确诊新型冠状病毒感染病例40例，一例死亡，没有明显的人传人证据，香港，日本，泰国也有报道有同样病例。

傲慢与偏见

对WH-HUMAN-1和新公布的冠状病毒序列，以及SARS和MERS序列进行比较。六个新型武汉冠状病毒基因组基本一致
WH-HUMAN-1和SARS病毒序列同源性要高于和MERS序列
WH-HUMAN-1和SARS病毒两者之间的变异主要发生在ORF1A和刺突蛋白序列中
而WH-HUMAN-1和MERS-CoV两者这两个基因的同源性更差。